TOKYO (AP) Asian shares skidded again Tuesday on deepening worries over the expanding outbreak of a new virus in China.

Markets in Hong Kong and mainland China were closed Tuesday for Lunar New Year holidays, while South Koreas benchmark tumbled 3.4% to 2,170.88 as it reopened after its own holidays.

Japans Nikkei 225 index lost 0.9% to 23,128.24, while Australias S&P ASX/200 slipped 1.4% to 6,988.60. Shares also fell in Taiwan, Jakarta and Singapore.

China has extended its national holiday by three days so that offices should reopen on Monday. Shanghais holiday was extended until Feb. 9.

Overnight, a sell-off on Wall Street gave the Dow its first 5-day losing streak since early August and handed the S&P 500 its worst day since early October. The latest bout of selling on Wall Street came after China announced a sharp rise in cases of the virus.

How long and how deep the correction lower will last, depends both on the success of Chinas efforts to control the viral spread, and the prevalence of its occurrence internationally, Jeffrey Halley of Oanda said in a commentary.

Airlines, resorts and other companies that rely on travel and tourism suffered steep losses. Gold prices rose as did bonds as traders sought refuge in safer holdings.

Over the weekend you saw more cases, said Quincy Krosby, chief market strategist at Prudential Financial. That got investors and traders worried that this may be a longer event. The next question is, What happens to global growth if this does continue and magnify?

The Dow Jones Industrial Average fell 453.93 points, or 1.6%, to 28,535.80. The Dow had been down nearly 550 points. The S&P 500 index dropped 51.84 points, or 1.6%, to 3,243.63. The Nasdaq lost 175.60 points, or 1.9%, to 9,139.31. The Russell 2000 index of smaller company stocks gave up 18.09 points, or 1.1%, to 1,644.14.

The virus has spread to a dozen countries, including the U.S. Besides the threat to peoples lives and health, investors are worried about how much damage the virus will do to profits for companies around the world.

Even if theyre thousands of miles away from Wuhan, the interconnected global economy means U.S. companies have plenty of customers and suppliers in China. Its the worlds second-largest economy, and it accounts for 6% of all revenue for S&P 500 companies over the last 12 months. Thats nearly double any other country besides the United States, according to FactSet.

Markets hate uncertainty, and the coronavirus is the ultimate uncertainty in that no one knows how badly it will impact the global economy, said Alec Young, managing director of global markets research at FTSE Russell.

Resort operators were among the biggest losers in the S&P 500. Wynn Resorts led all companys in the index lower with an 8.1% tumble, while Las Vegas Sands dropped 6.7%. The companies get most of their revenue from the Chinese gambling haven of Macao. MGM Resorts fell 3.9%.

American Airlines lost 5.5% and Delta dropped 3.4% as part of a broad slide for airlines because of concerns international travel will decline amid the virus spread.

Booking companies and cruise-line operators also got hurt. Expedia Group fell 2.7% and Carnival slid 4.7%.

Chinese companies that trade shares in the U.S. also declined. Search engine operator Baidu fell 2.9% and e-commerce company dropped 4.8%.

The technology sector, the biggest in the S&P 500, also saw heavy selling. Apple, which relies on China for supplies and sales, fell 2.9%.

Financial stocks also took steep losses. Citigroup dropped 2.2%.

Energy stocks fell broadly as U.S. oil prices fell 1.9% on worries about reduced demand from China. Schlumberger skidded 5.1%.

Utilities, real estate stocks and household goods makers held up better than the rest of the market, though they still finished in the red. The sectors are viewed as less-risky and are not as affected by international issues and developments.

Investors are also dealing with a heavy week of corporate earnings. Apple will report financial results on Tuesday. Pharmaceutical giant Pfizer and Starbucks will also report.

Boeing, McDonalds, Coca-Cola and Amazon are also among some of the biggest names reporting earnings throughout the week that includes 147 S&P 500 companies.

ENERGY: Benchmark crude oil lost 28 cents to $52.86 a barrel in electronic trading on the New York Mercantile Exchange Brent crude oil, the international standard, fell 37 cents to $58.21.

CURRENCIES: The dollar rose to 108.97 Japanese yen from 108.89 yen on Monday. The euro strengthened to $1.1022 from $1.1019.

AP Business Writers Alex Veiga and Damian J. Troise contributed.

Coronavirus has made 2011 movie, Contagion, a hot rental on Amazon Prime, iTunes

Will coronavirus spread in the U.S.? What Americans can learn from mistakes made during those critical, early days in China

Popes Sunday prayer to be livestreamed as coronavirus spreads

Cruise ships seek safe harbour as anti-virus controls widen

Hotel in China being used for coronavirus quarantine collapses with 70 inside, reports say

The crazy story of Purell and the coronavirus

Will coronavirus end the longest bull market in history for stocks?

Lawsuit alleges college textbook publishers conspired to monopolize the market

Coronavirus outbreak may have unleashed panic buying of Hostess Twinkies and Ding Dongs

These are the safest and highest dividend-yielding REITs as the coronavirus spreads, BofA says

Were about to find out how worried Americans are about coronavirus

Im a financially bullied husband. My wife makes $500,000 5 times my income and tells me to live in a motor home. What will happen if we divorce?

Coronavirus update: 101,733 cases, 3,460 deaths, U.S. grocers see sales jump as Americans prepare

Melania Trump responds to everyone who chooses to be negative about White House tennis court amid the coronavirus

Missing toddlers remains believed to be found

West Coast manufacturing equipment online marketplace grows Chandler office

Scaramucci: Im willing to campaign with Obama against Trump in swing states

Trump administration plan to sunset the Public Service Loan Forgiveness Program would be devastating, expert says

3 micro-cap names that may capture unicorn-like growth: Analyst

Trump replaces chief of staff Mick Mulvaney with Rep. Mark Meadows

The stock markets big swings indicate a top or a bottom heres how to decide