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London (CNN Business)Around the world, countries are issuing emergency approvals of the Pfizer-BioNTech Covid-19 vaccine. Now transportation and logistics companies face a huge challenge: Gettingmillions of dosesto people who need them at hospitals, clinics and care homes.

Airlines will be at the center of the effort. Delivering vaccines will require an estimated 8,000 flights, according to the International Air Transport Association.

The British pound could be heading for a crash

But officials returned to the negotiating table and theUnited Kingdom and the European Union announced on Sunday that talks would be extendedonce again. Sunday had been the latest self-imposed deadline.

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Currency traders who once assumed a deal would be completed before a Brexit transition period ends on Jan. 1 have been nervously watching the latest signals out of London and Brussels.

vaccine could also be imminent, following reviews that showed it was both safe and effective.

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We took that product and we amended it, Francesco Incalza, president Thermo King Europe, Middle East and Africa, told me.

will oversee a highly coordinated set of movements from a command center in Louisville, Kentucky.

Everybody needs this vaccine, said Gates, the co-chair of the Bill and Melinda Gates Foundation. If we only get it to the high-income countries, this disease is going to bounce around. Were going to see twice as many deaths.

Investors are likely to see the extension as a positive sign. But they wont be able to fully relax until a deal has been finalized.

My colleagues Gregory Wallace and Pete Muntean report that within 24 hours of an emergency use authorization from the US Food and Drug Administration, manufacturers and shippersare preparedto activate the delivery chain a complex system that involves warehouses, trucks and planes. Planning, dry runs and stockpiling are already underway.

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The British poundcould plungeif the United Kingdom does not finalize a trade deal with the European Union, my CNN Business colleague Charles Riley reports.

, meanwhile, says it has more than 90 cold storage facilities worldwide to help keep the Pfizer vaccine sufficiently cold.

governments and logistics firms to ensure vaccines stay frozen as they travel to clinics and hospitals.A version of this story first appeared in CNN Business Before the Bell newsletter. Not a subscriber? You can sign upTuna must be stored at -60 degrees Celsius,Incalza said. The Pfizer-BioNTech vaccine has to be stored at -70 degrees Celsius,Han Tan,government aid for companies and how disputes would be settled.Businesses have been preparing for this moment for months. Thermo King which revolutionized the transportation of food through advances in temperature-controlled shipping before World War II has been working with pharmaceutical companies,The binary outcome [deal or no-deal] is on a knifes edge which potentially sets the pound up for an outsized move once the Brexit saga reaches its finale,he could afford steak. Now he can afford McDonaldsIts just one example of how companies stand at the ready to handle the delicate,which requires similar frigid conditions.Bill Gates: Next 4 to 6 months could be worst of the pandemicThese restaurant owners dont know how long they can hang onWhats happening: The US Food and Drug Administration has authorized the vaccine for emergency use. The United Kingdom and Canada have given the green light to begin distribution.European Union expected to propose new tech regulations;said in a research note Friday. The fact that the pound hasnt yet capitulated against the dollar suggests theres still pent-up hope that a deal will be secured,US industrial production data;or -94 degrees Fahrenheit,complex process of vaccine distribution.Frustrated restaurant owner blasts shutdown in viral postMelinda Gates: Vaccines need to reach the far corners of the globeBut the United States isnt alone in requiring coordination. In arecent interviewwith CNNs Poppy Harlow,while in transit.To make this happen,to maintain its quality and deep red hue when it reaches supermarkets and restaurants,

says its wide-body Boeing 787 jetliners can carry about a half-million vaccine doses. It began running test flights between South America and Miami in November.

vaccine by land or sea. Some have already been sold and are making their way around the globe.

So Thermo King, which is part of Ireland-based Trane Technologies, made some tweaks, adding additional insulation and adjusting the refrigeration system so it could get even colder. Now, each 20-foot-long container can carry 300,000 doses of the

he added.Germany set to enter hard lockdown as coronavirus cases surgePre-pandemic,Melinda Gates urged leaders of wealthy countries not to forget about the rest of the world.UK Prime Minister Boris Johnson traveled to Brussels last week for dinner with European Commission President Ursula von der Leyen. The trip failed to produce a breakthrough on thorny issues including fishing rights,a market analyst at FXTM,theyve reworked containers typically used to transport fresh tuna to Japan,or -76 degrees Fahrenheit.

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The pound was trading close to $1.35 earlier this month when an agreement between the United Kingdom and its biggest export market looked more likely. Analysts have warned that the currency could quickly plunge to $1.20 if it becomes clear that a deal is no longer possible. On Friday, it hovered near $1.32, a 0.6% decline.

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